Papers - ASHITAKA Emiko
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Dermal macrophages control tactile perception under physiological conditions via NGF signaling
Tanaka T, Isonishi A, Banja M, Yamamoto R, Sonobe M, Okuda-Ashitaka E, Furue H, Okuda H, Tatsumi K, Wanaka A. ( Multiple Authorship )
Scientific Reports 14 27192 2024.11
Research paper (scientific journal) English
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Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.
Hagihara H, Okuda-Ashitaka E, Miyakawa T 他 ( Multiple Authorship with a faculty member from an overseas university )
eLife 12 RP89376 2024.03
Research paper (scientific journal) English
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Hypersensitivity of myelinated A-fibers via toll-like receptor 5 promotes mechanical allodynia in tenascin-X-deficient mice associated with Ehlers-Danlos syndrome.
Kamada H, Emura K, Yamamoto R, Kawahara K, Uto S, Minami T, Ito S, Matsumoto KI, Okuda-Ashitaka E. ( Multiple Authorship )
Scientific Reports 13 18490 2023.10
Research paper (scientific journal) English
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Tenascin-X as a causal gene for classical-like Ehlers-Danlos syndrome
Emiko Okuda-Ashitaka, Ken-ichi Matsumoto ( Multiple Authorship )
Front Genet 14 1107787 2023.03
Research paper (scientific journal) English
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TLR4/MD‑2 is a receptor for extracellular nucleophosmin 1
Nakatomi K, Ueno H, Ishikawa Y, Salim RC, Mori Y, Kanemoto I, Tancharoen S, Kikuchi K, Miura N, Omori T, Okuda-Ashitaka E, Matsumura K, Imaizumi H, Motomiya Y, Maruyama I, Kawahara KI. ( Multiple Authorship )
Biomed Rep. 14 21 2021.02
Research paper (scientific journal) English
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Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome
Okuda-Ashitaka, E., Kakuchi, Y., Kakumoto, H., Yamanishi, S., Kamada, H., Yoshidu, T., Matsukawa, S., Ogura, N., Uto, S., Minami, T., Ito, S., and Matsumoto, K.-I. ( Multiple Authorship )
Scientific Reports 10 6569 2020.04
Research paper (scientific journal) English
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Development of a novel photoaffinity probe for labeling nocistatin receptor
Harada, M., Minami, T., Ito, S., and Okuda-Ashitaka, E. ( Multiple Authorship )
Biochem. Biophys. Res. Commun. 201 514 - 519 2018.06
Research paper (scientific journal) English
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Intrathecal administration of low-dose nociceptin/orphanin FQ induces allodynia via c-Jun N-terminal kinase and monocyte chemoattractant protein-1.
Kawabata, K., Nishimura, I., Fujiwara, T., Terauchi, S., Minami, T., Ito, S., and Okuda-Ashitaka, E. ( Multiple Authorship )
Eur. J. Neurosci.43:1499-1508 43 ( 11 ) 1499 - 1508 2016.05
Research paper (scientific journal) English
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Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain.
Okamoto, K., Ohashi, M., Ohno, K., Takeuchi, A., Matsuoka, E., Fujisato, K., Minami, T., Ito, S., and Okuda-Ashitaka, E. ( Multiple Authorship )
Mol. Pain 12 1 - 11 2016.03
Research paper (scientific journal) English
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Controllable urokinase gene expression in trabecular meshwork cells.
Tsuda, M., Kaneko, S., Ando, A., Nishimura, T., Okuda-Ashitaka, E., Ito, S., Taomoto, M., Matsumura, M., and Takahashi, K. ( Multiple Authorship )
J Clin Exp Ophthalmol 5 ( 2 ) 329 2014.03
Research paper (scientific journal) English
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Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission
Okuda-Ashitaka, E., Minami, T., Tsubouchi, S., Kiyonari, H., Iwamatsu, A., Noda, T., Handa, H., and Ito, S. ( Multiple Authorship )
J. Biol. Chem. 287 10403 - 10413 2012.03
Research paper (scientific journal) English
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Induction of arginase II mRNA by nitric oxide using in vitro model of gyrate atrophy of choroid and retina.
Ohnaka, M., Okuda-Ashitaka, E., Kaneko, S., Ando, A., Maeda, M., Furuta, K., Suzuki, M., Takahashi, K., and Ito, S. ( Multiple Authorship )
Invest. Ophthalmol Vis. Sci., 52 1493 - 1500 2011.03
Research paper (scientific journal) English
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A novel role of prostaglandin E2 in neuropathic pain: blockade of microglialmigration in the spinal cord.
Kunori, S., Matsumura, S., Okuda-Ashitaka, E., Katano, T., Audoly, A.P., Urade, Y., and Ito, S. ( Multiple Authorship )
Glia 59 208 - 218 2011.02
Research paper (scientific journal) English
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Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury.
Matsumura, S., Takagi, K., Okuda-Ashitaka, E., Lu, J., Naritsuka, H., Yamaguchi, M., and Ito, S. ( Multiple Authorship )
Neuroscience 170 942 - 953 2010.10
Research paper (scientific journal) English
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Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472.
Matsumura, S., Kunori, S., Mabuchi, T., Katano, T., Nakazawa, T., Abe, T., Watanabe, M., Yamamoto, T., Okuda-Ashitaka, E., Ito, S. ( Multiple Authorship )
Eur. J. Neurosci. 32 798 - 810 2010.09
Research paper (scientific journal) English
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Cytoprotection by nipradiol, an anti-glaucomatous agent, via down-regulatoion of apoptosis related gene expression and activation of NF-κB.
Ando, A., Yamazaki, Y., Kaneko, S., Miyake, M., Nambu, R., Taomoto, M., Unezaki, S., Okuda-Ashitaka, E., Okumura, T., Ito, S. and Matsumura, M. ( Multiple Authorship )
Exp. Eye Res. 80 501 - 507 2005
Research paper (scientific journal) English
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Rho-kinase mediates spinal nitric oxide formation by prostaglandin E2 via EP3 subtype.
Matsumura, S., Abe, T., Mabuchi, T., Katano, T., Takagi, K., Okuda-Ashitaka, E., Tatumi, S., Nakai, Y., Sasaki, Y., Minami, T. and Ito, S. ( Multiple Authorship )
Biochem. Biophys. Res. Commun. 338 550 - 557 2005
Research paper (scientific journal) English
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Monitoring for dynamic biological processing by intra-molecular bioluminescence resonance energy transfer system using secreted luciferase.
Otsuji, T., Okuda-Ashitaka, E., Kojima, S., Akiyama, H., Ito, S. and Ohmiya, Y. ( Multiple Authorship )
Anal. Biochem. 329 230 - 237 2004
Research paper (scientific journal) English
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Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain.
Mabuchi, T., Shintani, N., Matsumura, S., Okuda-Ashitaka, E., Hashimoto, H., Muratani, T., Minami, T., Baba, A. and Ito, S. ( Multiple Authorship )
J. Neurosci. 24 7283 - 7291 2004
Research paper (scientific journal) English
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Characterization of the isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as transcription factor.
Unezaki, S., Nishizawa, M., Okuda-Ashitaka, E., Masu, Y., Mukai, M., Kobayashi, S., Sawamoto, K., Okano, H. and Ito, S. ( Single Author )
Gene 336 47 - 58 2004
Research paper (scientific journal) English
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Attenuation of neuropathic pain by nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.
Mabuchi,T., Matsumura, S., Okuda-Ashitaka, E., Kitano, T., Kojima, H., Nagano, T.,Minami, T. and Ito, S. ( Single Author )
Eur. J. Neurosci. 17 1384 - 1392 2003
Research paper (scientific journal) English
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Nociceptin, Nocistatin and Pain.
Zeilhofofer, H. U., Reinscheid, R. K., and Okuda-Ashitaka, E. ( Multiple Authorship with a faculty member from an overseas university )
Proceeding of the 10th World Congress on Pain, Progress in Pain Reserch and Management 24 469 - 480 2003
Research paper (scientific journal) English
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Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist JTC-801.
Muratani, T., Minami, T., Enomoto, U., Sakai, M., Okuda-Ashitaka, E., Kiyokane, K., Mori, H. and Ito, S. ( Single Author )
J. Pharmacol. Exp. Ther. 303 424 - 430 2002
Research paper (scientific journal) English
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Characterization of the glutamatergic system for induction and maintenance of allodynia.
Minami, T., Matsumura, S., Okuda-Ashitaka, E., Shimamoto, K., Sakimura, K., Mishina, M., Mori, H. and Ito, S. ( Multiple Authorship )
Brain Res. 895 178 - 185 2001
Research paper (scientific journal) English
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Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and NMDA receptor epsilon subunit knockout mice.
Minam, T., Okuda-Ashitaka, E., Mori, H., Sakimura, K., Watanabe, M., Mishina, M. and Ito, S. ( Multiple Authorship )
Neuroscience 97 133 - 142 2000
Research paper (scientific journal) English
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Effect of intrathecal nocistatin on the formalin-induced pain in mice versus that of nociceptin/orphanin FQ.
Nakano, H., Minami, T., Abe, K., Arai, T., Tokumura, M., Ibii, N., Okuda-Ashitaka, E., Mori, H. and Ito, S. ( Multiple Authorship )
J. Pharmacol. Exp. Ther. 292 331 - 336 2000
Research paper (scientific journal) English
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cDNA cloning, expression and charcterization of human prostaglandin F synthase.
Suzuki-Yamamoto, T., Nishizawa, M., Fukui, M., Okuda-Ashitaka, E., Nakajima, T., Ito, S. and Watanabe, K. ( Multiple Authorship )
FEBS lett. 462 355 - 340 1999
Research paper (scientific journal) English
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Strucutre-activity relationships of nocistatin: a novel peptide blocking nociceptin-induced hyperalgesia and allodynia.
Okuda-Ashitaka, E., Minami. T., Tachibana, S., Yoshihara, Y., Nishiuchi,Y., Kimura,T. and Ito, S. ( Multiple Authorship )
Peptide 1998, Proceeding of the 25th European Peptide Symposium 736 - 737 1999
Research paper (international conference proceedings) English
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Identification of human, rat and mouse nocistatin in brain and human cerebrospinal fluid.
Lee, T-L., Fung, F. M. Y., Chen, F-G., Chou, N., Okuda-Ashitaka, E., Ito, S., Nishiuchi, Y., Kimura, T. and Tachibana, S. ( Multiple Authorship with a faculty member from an overseas university )
NeuroReport 10 1537 - 1541 1999
Research paper (scientific journal) English
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Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.
Ikeda, S., Okuda-Ashitaka, E., Masu, Y., Suzuki, T., Watanabe, K., Nakao, M., Shingu, K. and Ito, S. ( Multiple Authorship )
FEBS lett. 459 433 - 437 1999
Research paper (scientific journal) English
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Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices.
Nicol, B., Lambert, D. G., Rowbotham, D. J., Okuda-Ashitaka, E., Ito, S., Smart, D. and McKnight, A. T. ( Multiple Authorship with a faculty member from an overseas university )
Eur. J. Pharmacol. 356 R1 - R3 1998
Research paper (scientific journal) English
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Strucutre-activity relationships of nocistatin: a novel peptide blocking nociceptin action in pain transmission.
Okuda-Ashitaka, E., Minami. T., Tachibana, S., Yoshihara, Y., Nishiuchi,Y., Kimura,T. and Ito, S. ( Multiple Authorship )
Peptide science 1998, Proceeding of the 35th Japan Peptide Symposium ( 209 ) 212 1998
Research paper (international conference proceedings) English
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Nocistatin, a peptide that blocks nociceptin action in pain transmission.
Okuda-Ashitaka, E., Minami, T., Tachibana, S., Yoshihara, Y., Nishiuchi, Y., Kimura, T. and Ito, S. ( Multiple Authorship )
Nature 392 286 - 289 1998
Research paper (scientific journal) English
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Expression of murine novel zinc finger proteins highly homologous to Drosophila ovo gene product in testis.
Masu, Y., Ikeda, S., Okuda-Ashitaka, E., Sato, E. and Ito, S. ( Multiple Authorship )
FEBS lett. 421 224 - 228 1998
Research paper (scientific journal) English
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Anti-nociceptive responses produced by human putative counterpart of nocistatin.
Minami, T., Okuda-Ashitaka, E., Nishiuchi, Y., Kimura, T., Tachibana, S., Mori, H. and Ito, S. ( Multiple Authorship )
Br. J. Pharmacol. 124 1016 - 1018 1998
Research paper (scientific journal) English
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Inhibition of nociceptin-induced allodynia in conscious mice by prostaglandin D2.
Minami, T., Okuda-Ashitaka, E., Nishizawa, M., Mori, H. and Ito, S. ( Multiple Authorship )
Br. J. Pharmacol. 122 605 - 610 1997
Research paper (scientific journal) English
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Genomic organization and characterization of the bovine prostaglandin F2 alpha receptor gene.
Ezashi, T., Sakamoto, K., Miwa, K., Okuda-Ashitaka, E., Ito, S. and Hayaishi, O. ( Multiple Authorship )
Gene 190 271 - 278 1997
Research paper (scientific journal) English
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Characterization of nociceptin, a novel opioid peptide, for pain transmission in conscious mice.
Hara,N., Minami, T., Okuda-Ashitaka, E., Sugimoto, T., Sakai, M., Onaka, M., Mori, H., Imanishi, T., Shingu, K. and Ito, S. ( Multiple Authorship )
Br. J. Pharmacol. 121 401 - 408 1997
Research paper (scientific journal) English
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Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: its involvement in allodynic response to innocuous stimulus.
Okuda-Ashitaka, E., Tachibana, S., Houtani, T., Minami, T., Masu, Y., Nishi, M., Takeshima, H., Sugimoto, T. and Ito, S. ( Multiple Authorship )
Mol. Brain. Res. 43 96 - 104 1996
Research paper (scientific journal) English
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Suppression of prostaglandin E receptor signaling by the variant form of EP1 subtype.
Okuda-Ashitaka, E., Sakamoto, K., Ezashi, T., Miwa K., Ito, S. and Hayaishi, O. ( Multiple Authorship )
J.Biol. Chem. 271 31255 - 31261 1996
Research paper (scientific journal) English
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Prostaglandin D2 inhibits prostaglandin E2-induced allodynia in conscious mice.
Minami, T., Okuda-Ashitaka, E., Mori, H., Ito, S. and Hayaishi, O. ( Multiple Authorship )
J. Pharmacol. Exp. Ther. 278 1146 - 1152 1996
Research paper (scientific journal) English
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L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2.
Minami, T., Onaka, M., Mori, H., Okuda-Ashitaka, E., Ito, S. and Hayaishi, O. ( Multiple Authorship )
Neurosci. Lett. 201 239 - 242 1995
Research paper (scientific journal) English
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Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor.
Sakamoto, K., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Houtani, T., Sugimoto, T., Ito, S. and Hayaishi, O. ( Multiple Authorship )
Advances in Prostaglandin, Thromboxane, Leukotriene Res. 23 259 - 261 1995
Research paper (international conference proceedings) English
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Expression of mRNA encoding the prostaglandin F2alpha receptor in the bovine corpora lutea throughout the oestrous cycle and pregnancy.
Sakamoto, K., Miwa, K., Ezashi, T., Okuda-Ashitaka, E., Okuda, K., Houtani, T., Sugimoto, T., Ito, S. and Hayaishi, O. ( Multiple Authorship )
J. Reprod. Fertil. 103 99 - 105 1994
Research paper (scientific journal) English
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Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor.
Sakamoto, K., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Houtani, T., Sugimoto, T., Ito, S. and Hayaishi, O. ( Multiple Authorship )
J. Biol. Chem. 269 3881 - 3856 1994
Research paper (scientific journal) English
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Prostaglandin F2 alpha receptor is coupled to Gq in cDNA-transfected Chinese hamster ovary cells.
Ito, S., Sakamoto, K., Mochizuki-Oda, N., Ezashi, T., Miwa, K., Okuda-Ashitaka, E., Shevchenko, V. I., Kiso, Y. and Hayaishi, O. ( Multiple Authorship )
Biochem. Biophys. Res. Commun. 200 756 - 762 1994
Research paper (scientific journal) English
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Cyclic-AMP-dependent Ca2+ influx elicited by prostaglandin D2 in freshly isolated nonchromaffin cells from bovine adrenal medulla.
Okuda-Ashitaka, E., Sakamoto, K., Giles, H., Ito, S. and Hayaishi, O. ( Multiple Authorship )
Biochim. Biophys. Acta. 1176 148 - 154 1993
Research paper (scientific journal) English
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Endothelin stimulates both cAMP formation and phosphatidylinositol hydrolysis in cultured embryonic bovine tracheal cells.
Oda, K., Fujitani, F., Watanabe, T., Inui, T., Okada, T., Urade, Y.,Okuda-Ashitaka, E. and Ito, S. ( Multiple Authorship )
FEBS Lett. 299 187 - 191 1992
Research paper (scientific journal) English
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Cyclic AMP-mediated inhibition of cell growth by prostaglandin D2 in a fibroblastic cell line (EBTr).
Okuda-Ashitaka, E., Negishi, M., Sugama, K., Hatanaka, M. and Ito, S. ( Multiple Authorship )
Eicosanoids 3 231 - 218 1990
Research paper (scientific journal) English
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Signal transduction coupled to prostaglandin D2.
Ito, S., Negishi, M., Sugama, K., Okuda-Ashitaka, E. and Hayaishi, O. ( Multiple Authorship )
Advances in Prostaglandin, Thromboxane, Leukotriene Res. 21 71 - 74 1990
Research paper (international conference proceedings) English
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Evaluation of ZK110841 and AH6809, an agonist and an antagnist of prostaglandin DP-receptors on human platelets, with a PGD2-responsive cell line from bovine embryonic trachea.
Ito, S., Okuda, E., Sugama, K., Negishi, M. and Hayaishi, O. ( Multiple Authorship )
Br. J. Pharmacol. 99 13 - 14 1990
Research paper (scientific journal) English